Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins

Neutrophils and eosinophils are granulocytes which characterized by the presence of granules in cytoplasm. Granules provide a safe storage site for granule proteins that play important roles immune function granulocytes. Upon activation, diverse released from into extracellular space contribute to fight against infections. In this article, we describe both neutrophils able kill pathogens review their anticipated mechanism antimicrobial toxicity. It should be noted an excess protein release can lead tissue damage host resulting chronic inflammation organ dysfunction.